NEW ORLEANS -- Half of last year's Final Four flopped Sunday.
North Carolina and Florida were eliminated in back-to-back shockers in the second round of the NCAA tournament.
Seventh-seeded Penn State beat the No. 2 Tar Heels 82-74 in the Superdome in New Orleans right after No. 11 Temple took care of the No. 3 Gators 75-54 on the same court in the South.
Penn State, in the round of 16 for the first time since 1955, plays Temple in Atlanta on Friday.
North Carolina's loss completed a stunning spiral for a team that in mid-February was ranked No. 1 and riding an 18-game winning streak under first-year coach Matt Doherty. The Tar Heels lost four of their last eight games heading into the NCAAs, including a 79-53 drubbing against Duke in the ACC tournament final.
Titus Ivory, Joe Crispin and Gyasi Cline-Heard combined for 61 points for Penn State, which was outshot 47 percent to 44 percent and was outrebounded 44-33. But the Nittany Lions had half as many turnovers as the Tar Heels.
''It was a frustrating game,'' Doherty said. ''They had 28 points off turnovers and that hurt. I don't know if I'll ever watch the tape. You can't turn the ball over 22 times and expect to win the game.''
UNC has made 27 straight NCAA tourney appearances, won three national championships and produced such stars as Michael Jordan, James Worthy and Vince Carter. Penn State, by contrast, has made just three NCAA appearances in the past 35 years and never has had an All-American.
Temple, meanwhile, used its trademark matchup zone defense to shut down Florida's up-tempo shooters and shut off passing lanes. With six minutes left, the Gators had only 13 baskets and 11 turnovers.
''We've been walking a tight wire for the last 4-to-5 weeks,'' Temple coach John Chaney said. ''With what they've accomplished, I've got to applaud them.''
Top-seeded Michigan State, which defeated Florida in the 2000 NCAA title game, and No. 12 Gonzaga also advanced in the South.
In Memphis, Tenn., Michigan State beat No. 9 Fresno State 81-65, while Gonzaga topped No. 13 Indiana State 85-68.
The Midwest held to form Sunday, with the top four seeds -- Illinois, Arizona, Mississippi and Kansas -- headed to San Antonio for the regional semifinals.
No. 3 Mississippi edged Notre Dame 59-56.Ole Miss next faces second-seeded Arizona, which beat Butler 73-52.
In Dayton, Ohio, No. 1 Illinois beat Charlotte 79-61 to set up a game against Kansas, which easily defeated Syracuse 87-58.
Penn State 82, North Carolina 74
Ivory and Crispin each scored 21 as Penn State became the first team to beat North Carolina this season while being outshot. The Tar Heels took a 19-8 lead seven minutes into the game and didn't allow Penn State (21-11) to grab an offensive rebound until 14 1/2 minutes had elapsed. But the Nittany Lions opened the second half with a 16-6 run and led 55-46 with 13:11 remaining.
Temple 75, Florida 54
Florida's point total matched the lowest in coach Billy Donovan's five years at the school. The Gators (24-7) shot only 18-for-50 overall, including 8-for-29 on 3-pointers.
Quincy Wadley had 24 points and 10 rebounds for Temple (23-12). Scoreless for the opening 11 minutes, he sparked a 14-0 run late in the first half that put the Owls in front for good.
Michigan St. 81, Fresno St. 65
The Spartans (26-4) had eight players score six or more points and moved into the round of 16 for the fourth consecutive year, tying Duke for the longest current streak.
Gonzaga 85, Indiana State 68
Casey Calvary scored 24 points and Dan Dickau added 20, making all 12 of his free throws, for Gonzaga (26-6).
Matt Renn's 3-pointer for Indiana State (22-12) tied the game at 60 with under eight minutes left, but Dickau answered with a jumper and two free throws to put Gonzaga ahead to stay.
Illinois 79, Charlotte 61
The Fighting Illini (26-7) won a second-round game for the first time since 1989, the only other time they had a No. 1 seed. Charlotte (22-11) missed 13 of its first 14 3-point attempts and never recovered.
Kansas 87, Syracuse 58
Drew Gooden had 17 points and a career-best 15 rebounds as the Jayhawks (26-6) built a double-figure lead early to snap a slide of second-round losses at three. Syracuse (25-9) had its fewest rebounds of the season, 23, to Kansas' 56.
Mississippi 59, Notre Dame 56
Mississippi's 5-foot-5 Jason Harrison pulled up and hit a 3-pointer with the shot clock winding down and just 46 seconds left to end Notre Dame's first NCAA appearance in 11 years.
Troy Murphy, a two-time All-American forward, had 17 points but was just 1-of-7 in the second half for Notre Dame (20-10).
Arizona 73, Butler 52
The Wildcats (25-7) won for the 17th time in 19 games and advanced to the regional semifinals for the fourth time in six years. Butler (24-8) went scoreless for nearly seven minutes during the second half.
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